The busy super human

2 days ago

New Hope For Migraine Sufferers

The US Food and Drug Administration (FDA) approved erenumab, an anti-CGRP receptor monoclonal antibody, for prevention of migraine in May 2018.
Calcitonin gene-related peptide (CGRP) is a signaling neuropeptide released from activated trigeminal (Cranial nerve 5 in the head/face) sensory afferents in headache, migraines and facial pain disorders.

The drug erenumab, is an anti-body which binds to the CGRP neuropeptide before it can bind to its receptor. In simple lay terms the way the drug Erenumab works. The CGRP neuropeptide which causes pain is like a key and the CGRP-receptor and Erenumab are like locks, so the The CGRP neuropeptide (the pain peptide) binds to the Erenumab and then there is not enough of it left to bind to the CGRP-receptor and create the symptoms of a headache or migraine.

The commonest side effects reported were injection site discomfort and nausea, but in many of the studies the same amount of people reported adverse effects in the control groups, who did not receive the anti migraine drug, but on the whole the drug is deemed 'safe'.

2 other anti-CGRP monoclonal antibodies have been submitted to the FDA for the indication of prevention of migraine, galcanezumab and fremanezumab. 1 small-molecule CGRP receptor antagonist (ubrogepant, MK-1602) is currently in phase 3 studies for the acute treatment of migraine.

Chronic migraine is defined as 15 or more headache days per month, of which eight or more were migraine days.

Tepper, SJ, Headache. 2018 Sep 22
Clin Neuropharmacol. 2017 Jul/Aug;40(4):169-174
Jain, S et al Pain Manag. 2018 Sep 21 ... See MoreSee Less

The busy super human

2 weeks ago

Can thin people be 'physiologically' obese? Why do some obese people have minimal biochemical issues?

As we know and scientific studies show, being obese or having visceral fat (internal abdominal fat) carries many health risks.
Genetically, some people are able to split fat cells more than others, which means they get bigger and bigger as more and more fat cells are made there is 'somewhere to store the energy' if they continue to overeat but the majority of the fat is stored visibly under the skin. Biochemically they arent insulin resistant or have poor lipid profiles.

On the other hand some normal weight people (skinny fat) , particularly of certain ethnicity, do not genetically split fat cells readily, meaning that the fat cells under the skin just fill up, then fat cells in the inside of the body (bad fat) fill up and become inflamed and release inflammatory cytokines. Under there circumstances the body tries to store fat in the liver and muscles, and the cells become insulin resistant in order to keep glucose out as there is already an energy abundance.

People of all sizes can become insulin resistant or pre-diabetic, so it is important to know your family history and do a fasted blood sugar test and check the reading. Insulin resistance is reversible without medication ... See MoreSee Less

The busy super human

2 weeks ago

The benefits of growth hormone (GH) are pretty extensive and they include:

anti-ageing, anti-inflammatory, anti-oxidant, faster recovery from exercise, healing tissue, neuron growth, improved brain function, increased bone density better vision, injury repair, better skin, hair growth, better sleep, improved immune system, anti-obesity and increase in lean muscle.

This is why people like to use GH as a supplement. So below is a very brief description of what happens naturally in the body.

Growth hormone release is not continuous; it is released in a number of ‘bursts’ or pulses from the pituitary gland every three to five hours when insulin levels are low (growth hormone and insulin oppose each other). Insulin is usually low in the morning, in between meals, during fasting, during and post workout and at night.

Growth hormone release is caused by another hormone (growth hormone-releasing hormone) which is released from a point higher up in the brain (the hypothalamus) and it causes the pituitary gland to release the growth hormone, this is why people like to use supplements like GHRP-2, Mod-GRF, Ipamorelin, hexarelin and such like.

Growth hormone travels in the blood to the liver, its major target organ and stimulates production of Insulin like growth factor -1 (IGF-1). This means that MOST of the effects of growth hormone are mediated or caused by IGF-1. IGF-1 ultimately inhibits growth hormone production by a negative feed back loop, saying ‘We have enough growth hormone at the moment, thank you’.

To read the rest of this post it is in my blog
www.busysuperhuman.com/igf/ ... See MoreSee Less

The busy super human

3 weeks ago

The amount of cognitive and physical load to rehab stroke or paralysis is FAR more than people think, according to neurologist it's almost the same amount of training as an elite athlete.

The training would be a mixture of brain based training including movement, visual, vestibular and digital cognitive fatigue drills such as stroop, Go-no-go, sustained attention.

A PVT ( psychomotor vigilant test ) is a KEY parameter to measure At the start and end of each session.
The PVT is also key for monitoring the progress of athletes under going neuro performance enhancing training AKA neuro doping. The aim of this type of training is to build mental resilience and delay mental and physical fatigue, which is utterly key to performance

The app I use and am trained in is SOMA by Grant Hayes of sswtich and you can read the current research to validate neuro cognitive loading as an effective tool for athletes and rehab

sswitch.ch/#research ... See MoreSee Less